Abcam, ab110905, Anti-CCT6A antibody

Size: 100µg
Rabbit Polyclonal CCT6A antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human CCT6A.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CCT6A. The exact immunogen used to generate this antibody is proprietary information.P40227

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab110905 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CCT6A also known as TCP-1-zeta or CCT-zeta acts as a component of the chaperonin-containing TCP-1 complex with a mass approximately 60 kDa. This complex facilitates protein folding in an ATP-dependent manner. Predominantly researchers find CCT6A in the cytoplasm of eukaryotic cells and it expresses in various tissues indicating its broad functional role.
Biological function summary
CCT6A plays an important role in folding newly synthesized proteins and refolding denatured proteins. It is a part of the essential chaperonin complex that consists of eight different subunits including CCT6A which collaborates to ensure correct protein conformation. This function supports cellular proteostasis maintaining the balance and health of the proteome which is critical for proper cell function and survival.
Pathways
CCT6A participates in the protein folding pathway and interacts with the protein catabolic processes. It plays an important part in pathways such as cytosolic protein folding and folding of actin and tubulin. Through these pathways CCT6A associates with proteins like HSP70 which also contributes to protein folding and stability signifying shared roles in maintaining cell homeostasis.
CCT6A's involvement impacts various neurodegenerative conditions and cancer. Misfolded proteins that are not adequately managed by chaperonin complexes including CCT6A are linked to diseases like Alzheimer's. In cancer the misregulation of protein folding pathways involving CCT6A might contribute to tumorigenesis. CCT6A holds connections with proteins such as p53 where impaired folding of tumor suppressors can lead to oncogenic outcomes.