Abcam, ab11168, Anti-TRPM2 antibody

Size: 50µg
Rabbit Polyclonal TRPM2 antibody. Suitable for IP, WB, IHC-P and reacts with Human, Rat samples. Cited in 27 publications. Immunogen corresponding to Synthetic Peptide within Human TRPM2 aa 650-700.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WB, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TRPM2 aa 650-700. The exact immunogen used to generate this antibody is proprietary information.O94759

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antibodies were affinity purified using the peptide immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.1% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRPM2 also known as Transient Receptor Potential Melastatin 2 is a calcium-permeable non-selective cation channel. Its molecular weight is approximately 171 kDa. TRPM2 is mainly expressed in the brain immune cells and pancreas. It responds to oxidative stress and other physiological stimuli facilitating calcium influx into the cell. This channel is involved in cellular signaling by mediating calcium entry triggered by hydrogen peroxide and ADP-ribose.
Biological function summary
This channel influences various cellular processes including apoptosis cytokine production and insulin secretion. As a part of a larger protein complex TRPM2 interacts with calmodulin and other related proteins to regulate calcium signaling. Its function in immune cells involves modulation of inflammation while in the pancreas it helps in regulating insulin release in response to glucose levels.
Pathways
TRPM2 plays a significant role in the reactive oxygen species (ROS) signaling pathway and the NF-κB pathway. It shares a connection with proteins like p38 MAPK and caspase proteins which are critical in mediating stress responses and apoptotic pathways. These interactions allow TRPM2 to act as a sensor and effector of cellular oxidative conditions triggering downstream signaling cascades.
Scientists associate TRPM2 with neurodegenerative disorders like Alzheimer's disease and conditions involving insulin resistance such as Type 2 diabetes. The channel's link to the Alzheimer's condition involves its interaction with amyloid-beta while in diabetes it relates to proteins such as insulin receptor substrate (IRS) proteins. Understanding these associations helps in exploring TRPM2 as a potential therapeutic target.