Abcam, ab112348, Recombinant Human RING1 protein

Size: 10µg
Recombinant Human RING1 protein is a Human Full Length protein, in the 1 to 377 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, SDS-PAGE, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q06587,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Product details:
useful for Antibody Production and Protein Array

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RING1 also known as Ring Finger Protein 1 or RNF1 is an E3 ubiquitin-protein ligase with a molecular mass of approximately 42 kDa. It is part of the polycomb group proteins known for regulating gene expression. RING1 is expressed ubiquitously in various tissues where it functions as an important regulator of protein degradation by tagging substrates with ubiquitin for proteasomal degradation. This activity plays a critical role in maintaining cellular homeostasis by controlling the abundance of regulatory proteins.
Biological function summary
Along with modulating protein turnover RING1 participates as a fundamental component of the Polycomb Repressive Complex 1 (PRC1). This complex is imperative in chromatin remodeling and transcriptional repression influencing epigenetic gene silencing. RING1 works in tandem with other proteins such as BMI1 facilitating histone ubiquitination and altering chromatin structure which impacts gene expression across different cell types and developmental stages.
Pathways
The ubiquitin-proteasome system and the epigenetic regulation pathway involve RING1. Within the ubiquitin-proteasome system RING1 interacts with other E3 ligases and ubiquitin-conjugating enzymes governing the fate of its protein substrates. In the epigenetic regulation pathway RING1's role in PRC1 places it alongside proteins like EZH2 contributing to the repression of genes involved in differentiation and development thereby ensuring proper cell identity maintenance.
Mutations or misregulation of RING1 have links to several conditions including cancers and neurodegenerative disorders. In cancer the disruption of normal RING1 functions can lead to unregulated cell proliferation due to improper gene silencing. For neurodegenerative disorders associations with proteins such as ubiquitin and its regulatory roles may contribute to disease pathogenesis by enabling the accumulation of misfolded proteins further highlighting its significance in cellular health and disease.