Abcam, ab113405, Anti-Sulfatase 2/SULF2 antibody [2B4]

Size: 50µg
Mouse Monoclonal Sulfatase 2/SULF2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SULF2.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:2B4,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human SULF2.Q8IWU5,
Epitope:ab113405 recognises an epitope located in the C terminal domain of Sulfatase 2/SULF2.,
Specificity:ab113405 shows no cross-reactivity with Sulfatase 1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Sulfatase 2 (SULF2) also known as SULF-2 or extracellular sulfatase acts as an enzyme that removes sulfate groups from the heparan sulfate proteoglycans (HSPGs). It is a 100-110 kDa protein located primarily on the cell surface. SULF2's expression occurs mainly in tissues such as the liver kidney and lungs although it can be found in various other tissues too. By modifying HSPGs SULF2 influences cell signaling events that are critical to cellular communication and function.
Biological function summary
SULF2 participates in the modulation of growth factor signaling and cell surface interactions. This enzyme does not exist in isolation; instead it functions as a part of complexes involved in the extracellular matrix (ECM). Through its catalytic action SULF2 modulates the availability and activity of signaling molecules such as fibroblast growth factors (FGFs) and Wnt proteins. It impacts processes such as cell proliferation differentiation and developmental processes by altering the structural properties of the ECM.
Pathways
SULF2 significantly modulates the Wnt signaling pathway and the fibroblast growth factor receptor (FGFR) pathway. These pathways play essential roles in development and tissue regeneration. By altering the sulfation states of heparan sulfate chains SULF2 affects the interaction of proteins like Frizzled receptors in the Wnt pathway and FGFRs in the FGF signaling pathway. This modulation leads to changes in signal transduction further influencing the cellular responses during growth and development.
SULF2 has been linked with several cancer types and neurodegenerative diseases. In cancer such as hepatocellular carcinoma SULF2 overexpression promotes tumor growth and invasion by influencing growth factor signaling. It often associates with proteins like β-catenin in cancer-related pathways. In neurodegenerative diseases SULF2 modulates neural stem cell differentiation and repair influencing conditions like Alzheimer's disease. The enzyme's interaction with amyloid-beta peptides and tau protein can impact disease progression and severity.