Abcam, ab113443, Anti-TMEM16B antibody

Size: 50µg
Rabbit Polyclonal TMEM16B antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ANO2 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ANO2 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q9NQ90

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM16B also known as ANO2 is a calcium-activated chloride channel with a mass of around 116 kDa. It plays a role in ion transport across the cell membrane. TMEM16B is expressed in various tissues most notably in the sensory neurons and the retina where it contributes to the function of sensory systems. Its activity depends on calcium presence allowing the passage of chloride ions which affects membrane potential and cellular signaling.
Biological function summary
TMEM16B influences processes like odor detection and vision. It acts as a component of a larger channel complex involved in the transduction of sensory signals. In olfactory sensory neurons TMEM16B modulates the signaling pathway by which odors lead to nerve impulses making it important for the sense of smell. In the retina it plays a role in photoreceptor signal regulation supporting proper vision.
Pathways
Protein TMEM16B interacts within the sensory transduction pathways including the visual and olfactory pathways. In the olfactory system it works with proteins like CNGA2 in the signaling cascade from odorant molecules to neuronal response. In the visual pathway TMEM16B collaborates with proteins involved in the phototransduction cascade impacting the conversion of light into electrical signals necessary for vision.
TMEM16B's malfunction links to anosmia and certain retinal degenerations. Alterations in its activity can lead to loss of smell as TMEM16B is necessary for signal propagation in olfactory neurons. In the retina its dysfunction may contribute to degenerative diseases linking with proteins like rhodopsin which plays a role in light detection. Understanding TMEM16B's role provides insight into these sensory disorders potentially guiding therapeutic strategies.