Abcam, ab114815, Recombinant Human GLEPP1/PTPRO protein

Size: 10µg
Recombinant Human GLEPP1/PTPRO protein is a Human Full Length protein, in the 1 to 598 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:Tag free,
Applications:SDS-PAGE, WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q16827,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.3% Glutathione

Product details:
This product was previously labelled as GLEPP1.

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GLEPP1/PTPRO also known as protein tyrosine phosphatase receptor type O is a receptor-type protein tyrosine phosphatase with a mass around 155 kDa. It is mainly expressed in epithelial cells like podocytes in the kidney glomerulus neurons in the brain and other tissues like liver and lung. GLEPP1/PTPRO catalyzes the removal of phosphate groups from tyrosine residues on proteins an action important for regulating protein function and signal transduction. In podocytes its activity helps maintain the filtration barrier of the kidney.
Biological function summary
GLEPP1/PTPRO participates in cellular growth differentiation and apoptosis. It forms part of the podocyte slit diaphragm complex important for maintaining the glomerular filtration function in kidneys. This protein also interacts with other cellular proteins to regulate signaling pathways that control cellular architecture. Its enzymatic activity influences cellular processes by altering the phosphorylation status of partner proteins.
Pathways
GLEPP1/PTPRO plays essential roles in the MAPK and JAK/STAT signaling pathways. Through these pathways the protein mediates cellular responses to external signals influencing processes like cell cycle progression and survival. It interacts with proteins like Jak2 in these pathways modulating their activities to maintain cellular homeostasis. This involvement emphasizes its importance in signaling impacting cellular responses to environmental changes.
GLEPP1/PTPRO is linked to kidney diseases such as focal segmental glomerulosclerosis (FSGS) and certain cancers. Its dysregulation can lead to abnormal podocyte function contributing to glomerular disease. Moreover in cancer alterations in its activity might affect cancer cell behavior promoting tumor progression. The relation of GLEPP1/PTPRO with proteins like nephrin highlights its contribution to maintaining healthy kidney function and its potential role in disease mechanisms.