Abcam, ab114829, Recombinant Human MEOX 2 protein

Size: 10µg
Recombinant Human MEOX 2 protein is a Human Full Length protein, in the 1 to 303 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P50222,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.3% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The MEOX2 protein also known as Mesenchyme Homeobox 2 or GAX is a homeobox-containing transcription factor with a mass of approximately 34 kDa. MEOX2 is expressed in developing mesoderm and neural crest during embryonic development. In adults its expression continues in various tissues including skeletal muscle and some parts of the central nervous system. This expression pattern indicates its role in both early development and maintenance of specific tissues.
Biological function summary
MEOX2 regulates the differentiation of mesodermal cells and contributes to skeletal muscle development. It acts as a transcription factor influencing the expression of a variety of downstream genes involved in cell cycle control and tissue morphogenesis. MEOX2 functions within a complex network of homeobox genes working together with other transcription factors to modulate cellular differentiation and organogenesis.
Pathways
The MEOX2 protein plays a significant role in the Wnt signaling and TGF-beta pathways. These pathways are important in cellular growth differentiation and development processes. MEOX2 interacts with proteins such as beta-catenin in the Wnt pathway influencing gene transcription linked to cell proliferation and differentiation. This coordination ensures the proper development and function of tissues where MEOX2 is expressed.
MEOX2 involvement has been linked to vascular diseases and muscular dystrophies. Altered expression of MEOX2 can disrupt vascular endothelium function contributing to the progression of vascular diseases like atherosclerosis. In muscular dystrophies MEOX2 interacts with other proteins such as myogenin and MyoD potentially affecting muscle cell differentiation and regeneration. Understanding these interactions and MEOX2's roles could provide insights into therapeutic targets for these conditions.