Abcam, ab116840, Recombinant Human CDS1 protein

Size: 10µg
Recombinant Human CDS1 protein is a Human Fragment protein, in the 1 to 98 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, SDS-PAGE, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q92903,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.3% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CDS1 also known as CDP-diacylglycerol synthase 1 plays an important mechanical role in lipid metabolism by converting phosphatidic acid into CDP-diacylglycerol. This enzyme has a molecular mass of approximately 52 kDa and is expressed in a wide range of tissues throughout the body with notable expression in the brain heart and lungs. CDP-diacylglycerol synthase 1 participates in phospholipid biosynthesis which is essential for maintaining cell membrane integrity and function.
Biological function summary
CDP-diacylglycerol synthase 1 contributes to the regulation of phospholipid synthesis influencing the production of important signaling molecules. It functions not by forming complex with other proteins but through its enzymatic activity that provides substrates for the synthesis of phosphatidylinositol and phosphatidylglycerol. These phospholipids are fundamental components of cell membranes and play roles in signaling pathways that control cellular activities.
Pathways
CDP-diacylglycerol synthase 1 is integral to the phosphatidylinositol signaling pathway and the glycerophospholipid metabolism pathway. These pathways are critical for many cellular processes including signal transduction and membrane trafficking. Within these pathways CDS1 works in conjunction with enzymes like phospholipase C which hydrolyzes phosphatidylinositol affecting intracellular second messengers. Its activity connects with other lipid metabolizing proteins to ensure proper cell function and survival.
Researchers have linked defects in CDP-diacylglycerol synthase 1 to certain developmental and metabolic diseases notably Lowe syndrome and skeletal disorders. Its dysfunction may disrupt normal phospholipid metabolism impacting cellular signaling and structural integrity. This enzyme's alteration can affect related proteins such as enzymes responsible for phosphatidylinositol levels contributing to disease pathogenesis and necessitating targeted interventions.