Abcam, ab116969, Recombinant Human S100A3 protein

Size: 10µg
Recombinant Human S100A3 protein is a Human Full Length protein, in the 1 to 101 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:SDS-PAGE, WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P33764,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.3% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
S100A3 also known as protein S100-A3 is a member of the S100 protein family characterized by calcium-binding motifs specifically the EF-hand motif. This protein has a molecular mass of approximately 11 kDa. S100A3 expresses primarily in tissues such as hair follicles and is particularly abundant in the filiform region of human hair cuticles. Its presence is significant in cellular compartments where it interacts with zinc and calcium ions suggesting a role in ion homeostasis and regulation.
Biological function summary
S100A3 participates in various cellular functions including cytoskeletal dynamics cell motility and differentiation. This protein does not form part of a larger complex but interacts closely with other proteins involved in maintaining cellular architecture and intracellular signaling. Its function involves modulating enzymatic activities and facilitating structural stability. The zinc-binding properties enhance the protein's ability to participate in structural organization and signaling pathways.
Pathways
S100A3 interacts with several signaling and regulatory pathways integral to cellular structure and function. It plays a role in the calcium signaling pathway influencing processes mediated by calcium ions including muscle contraction and neurotransmitter release. Additionally S100A3 participates in pathways related to cell differentiation through interactions with cytoskeletal proteins contributing to epithelial and hair follicle cell differentiation and growth.
S100A3 has been linked to conditions such as breast cancer and melanoma. Its interaction with calcium-binding proteins may affect tumor initiation and progression. In breast cancer S100A3 expression levels could correlate with tumor invasiveness where it might work together with proteins like S100A4. In melanoma variations in S100A3 expression could contribute to cell migration and invasion indicating its potential as a biomarker for disease progression and therapeutic targeting.