Abcam, ab117568, Anti-ZIP-3 antibody

Size: 50µg
Rabbit Polyclonal ZIP-3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SLC39A3 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SLC39A3 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q9BRY0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZIP-3 also known as SLC39A3 is a protein that functions as a zinc transporter facilitating the uptake of zinc into cells. This protein belongs to the solute carrier (SLC) family and typically has a mass of approximately 47 kDa. ZIP-3 localizes mainly to the plasma membrane and is expressed in a variety of tissues including liver kidney and intestine. It plays an important role in maintaining intracellular zinc homeostasis critical for various cellular functions.
Biological function summary
Zinc is essential for numerous cellular processes and ZIP-3 helps regulate its availability. Zinc acts as a cofactor for over 300 enzymes and plays a vital role in transcription factor function gene expression and cell signaling. Through these actions ZIP-3 impacts cellular proliferation differentiation and survival. ZIP-3 does not form part of a larger complex but works closely with other zinc transporters such as those from the ZIP and ZnT families to balance zinc levels in the body.
Pathways
Researchers have associated ZIP-3 with critical processes such as the metal ion transport and cellular response to stress. By modulating zinc levels ZIP-3 interacts with pathways like the MAPK signaling pathway which is pivotal for cell growth and division. In these pathways ZIP-3 operates alongside proteins like ZIP-4 and ZnT-1 ensuring proper zinc redistribution and cellular adaptation to changing environmental conditions.
Scientists have linked ZIP-3 dysfunction to conditions such as type 2 diabetes and neurodegenerative disorders. Abnormal ZIP-3 activity can disrupt zinc homeostasis contributing to insulin resistance in diabetes. In neurodegenerative diseases impaired zinc transport by ZIP-3 can lead to neuronal damage and cognitive deficits. Research also examines the interplay of ZIP-3 with other proteins such as insulin receptor substrate (IRS) in diabetes highlighting the potential for targeted therapeutic interventions.