Abcam, ab117776, Anti-Angiomotin antibody

Size: 100µL
Rabbit Polyclonal Angiomotin antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human AMOT aa 1000 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human AMOT aa 1000 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q4VCS5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab117776 was affinity purified using an epitope specific to Angiomotin immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: 99% Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Angiomotin also known as AMOT is a protein that has significant roles in various cellular processes. It has a molecular mass of approximately 130 kDa. Angiomotin is widely expressed across several tissues including endothelial cells where it functions as a regulator of cell migration and angiogenesis. It interacts directly with actin filaments affecting cell shape and movement therefore playing a role in the structural organization of cells.
Biological function summary
Angiomotin influences endothelial cell behavior through its involvement in cellular proliferation and mobility. Angiomotin forms part of a complex network by binding with other proteins such as Patj and LATS1/2 aiding in the control of the Hippo signaling pathway. This activity regulates organ size and cellular growth impacting tissue architecture and repair mechanisms in the body.
Pathways
Angiomotin's interactions contribute notably to the Hippo and MAPK signaling pathways. Within the Hippo pathway it aid the suppression of excessive cell proliferation by keeping the activity of YAP and TAZ in check. In the context of the MAPK pathway Angiomotin regulates signals that influence cell division and differentiation. The protein influences cellular outcomes by cooperating with other proteins like YAP a transcriptional coactivator often implicated in organ size and cancer.
Angiomotin is associated with various vascular conditions and cancers. Altered expression or dysregulation can contribute to pathological angiogenesis which plays a role in tumor progression and metastasis. In cancer Angiomotin impacts the Hippo pathway's ability to control YAP's oncogenic potential affecting cellular proliferation and tumor development. Understanding these interactions offers potential therapeutic targets for disorders linked to abnormal cell growth and vascular anomalies.