Abcam, ab120282, A 803467, NaV1.8 channel blocker

Size: 10mg / 50mg
MW 357.8 Da, Purity >98%. Selective blocker of Na V 1.8 channels (IC 50 = 8 nM for human Na V 1.8 ). Shows greater than 100-fold selectivity over human Na V 1.2, Na V 1.3, Na V 1.5, and Na V 1.7 (IC 50 values =1 μM). Shows no significant activity against TRPV1, P2X 2/3 , Ca V 2.2 and KCNQ2/3 channels. Antinociceptive.
Key facts
CAS number:944261-79-4,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:357.8 Da,
Molecular formula:C19H16ClNO4,
PubChem:16038374,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mM and in ethanol to 25 mM,
Biochemical name:5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide,
Biological description:Selective blocker of NaV1.8 channels (IC50 = 8 nM for human NaV1.8 ). Shows greater than 100-fold selectivity over human NaV1.2, NaV1.3, NaV1.5, and NaV1.7 (IC50 values =1 μM). Shows no significant activity against TRPV1, P2X2/3, CaV2.2 and KCNQ2/3 channels. Antinociceptive.,
Canonical smiles:COC1=CC(=CC(=C1)NC(=O)C2=CC=C(O2)C3=CC=C(C=C3)Cl)OC,
InChi:InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22),
InChiKey:VHKBTPQDHDSBSP-UHFFFAOYSA-N,
IUPAC Name:5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months