Abcam, ab120295, NS 398, COX-2 inhibitor

Size: 10mg / 50mg
MW 314.36 Da, Purity >98%. Selective cyclooxygenase-2 inhibitor (IC 50 values are 3.8 and >100 μM for COX-2 and COX-1, respectively). Orally active. Anti-inflammatory, antipyretic, analgesic and non-ulcerogenic in vivo . Induces apoptosis and cell cycle arrest.
Key facts
CAS number:123653-11-2,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:314.36 Da,
Molecular formula:C13H18N2O5S,
PubChem:4553,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mM,
Biochemical name:N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide,
Biological description:Selective cyclooxygenase-2 inhibitor (IC50 values are 3.8 and >100 μM for COX-2 and COX-1, respectively). Orally active. Anti-inflammatory, antipyretic, analgesic and non-ulcerogenic in vivo. Induces apoptosis and cell cycle arrest.,
Canonical smiles:CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2CCCCC2,
InChi:InChI=1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3,
InChiKey:KTDZCOWXCWUPEO-UHFFFAOYSA-N,
IUPAC Name:N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cyclooxygenase 2 (COX2) and Cyclooxygenase 1 (COX1) are enzymes that convert arachidonic acid into prostaglandins which are involved in inflammation and other physiological functions. COX2 also known as prostaglandin-endoperoxide synthase 2 has a molecular mass of approximately 72 kDa. COX1 sometimes called prostaglandin-endoperoxide synthase 1 has similar molecular weight. These enzymes are expressed in various tissues with COX1 found ubiquitously and COX2 expressed more selectively often induced by inflammatory stimuli.
Biological function summary
COX2 and COX1 help regulate processes like inflammation pain and fever through their role in prostaglandin synthesis. COX1 primarily maintains normal cellular processes while COX2 is highly inducible and becomes active during inflammatory responses. COX2 does not typically form complexes operating independently in the cellular environment to mediate inflammatory signals.
Pathways
COX2 and COX1 are key components in the prostaglandin biosynthetic pathway influencing pain and inflammatory pathways. Their activity affects the cyclooxygenase pathway important for converting arachidonic acid into prostaglandins and thromboxanes. COX enzymes interact closely with other proteins like prostaglandin synthases and thromboxane synthase which further modify their products into different prostaglandins and thromboxanes.
COX2 links to conditions such as rheumatoid arthritis and colorectal cancer. Its increased expression often correlates with the inflammatory response seen in these illnesses. Inhibiting COX2 with drugs like lumiracoxib alleviates symptoms in inflammatory diseases. COX1 while less implicated in disease connects to interactions with other proteins indicating changes during digestive issues due to its role in gastric mucosa maintenance.