Abcam, ab120341, H89 dihydrochloride, Kinase inhibitor

Size: 500µg / 1mg / 10mg / 50mg
MW 519.3 Da, Purity >98%. Kinase inhibitor, commonly used as a protein kinase A inhibitor (IC 50 = 135 nM). Also inhibits other kinases, including MSK1 , S6K1 and ROCKII (IC 50 values are 120, 80 and 270 nM, respectively).
Key facts
CAS number:130964-39-5,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:519.3 Da,
Molecular formula:C20H22BrCl2N3O2S,
PubChem:5702541,
Nature:Synthetic,
Biochemical name:H-89 Dihydrochloride,
Biological description:Kinase inhibitor, commonly used as a protein kinase A inhibitor (IC50 = 135 nM). Also inhibits other kinases, including MSK1 , S6K1 and ROCKII (IC50 values are 120, 80 and 270 nM, respectively).,
Canonical smiles:C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCNCC=CC3=CC=C(C=C3)Br.Cl.Cl,
Isomeric smiles:C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCNC/C=C/C3=CC=C(C=C3)Br.Cl.Cl,
InChi:InChI=1S/C20H20BrN3O2S.2ClH/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20;;/h1-10,12,15,22,24H,11,13-14H2;2*1H/b3-2+;;,
InChiKey:GELOGQJVGPIKAM-WTVBWJGASA-N,
IUPAC Name:N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide;dihydrochloride

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AKT3 also known as Protein Kinase B gamma is a serine/threonine kinase that plays an important role in cell survival and metabolism. Along with AKT2 a closely related isoform AKT3 shares structural similarities but differs in tissue distribution and specific functions. AKT3 has a molecular weight of approximately 56 kDa. It is expressed in brain heart and testis tissues. Its catalytic activity is regulated by phosphorylation at two key residues contributing to its activation state.
Biological function summary
AKT3 and AKT2 influence processes like glucose uptake cell proliferation and suppression of apoptosis. These proteins do not form a stable complex but interact with other proteins as part of their activation and signaling processes. The cAMP Protein Kinase Catalytic subunit often called PKA C or PKAc is involved in similar pathways regulating numerous cellular processes through phosphorylation events. ROCK2 or Rho-associated coiled-coil containing protein kinase 2 acts in cytoskeletal dynamics influencing cell shape and movement.
Pathways
AKT3 participates in the PI3K/AKT signaling pathway important for transmitting extracellular signals into the cell influencing growth and survival. In this pathway AKT3 and AKT2 interact with proteins like mTOR and GSK-3 which help regulate cell cycle progression and metabolism. ROCK2 is mainly involved in the RhoA/ROCK pathway modulating actin cytoskeleton organization and affecting processes such as contraction cell migration and proliferation.
AKT3 and AKT2 have been linked to cancer and insulin resistance. Mutations or aberrant activation can lead to excessive cell growth and survival contributing to tumorigenesis. Similarly dysregulation of AKT3 and AKT2 signaling can cause insulin resistance affecting glucose homeostasis. ROCK2 is connected to cardiovascular diseases influencing blood vessel tone and heart function. These proteins by being integral to these disease pathways present potential therapeutic targets and the use of kinase inhibitors like those targeting AKT and ROCK pathways can modulate their activity in disease contexts.