Abcam, ab214214, Anti-IDO-2 antibody

Size: 100µL
Rabbit Polyclonal IDO-2 antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human IDO2 aa 250-350 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human IDO2 aa 250-350 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q6ZQW0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Indoleamine 23-dioxygenase 2 (IDO-2) is an enzyme involved in tryptophan catabolism. IDO-2 is also known as INDOL1 or INDOLE-2. This enzyme differs from its counterpart IDO1 in its substrate specificity and tissue distribution. IDO-2 has a molecular mass of approximately 45 kDa. It is expressed in various tissues including liver kidney and placenta with notably higher expression in immune system cells like dendritic cells and macrophages.
Biological function summary
IDO-2 participates in the degradation of the essential amino acid tryptophan via the kynurenine pathway. This process helps modulate immune responses by reducing tryptophan availability and producing metabolites that affect T-cell function. IDO-2 is not known to be part of a larger protein complex but it does work in parallel with IDO1 to contribute to immune tolerance and homeostasis within the body.
Pathways
The kynurenine pathway prominently involves IDO-2 where it aids in the conversion of tryptophan to kynurenine influencing pathways related to immune regulation. IDO-2 interacts closely with enzymes such as tryptophan 23-dioxygenase (TDO) sharing roles in tryptophan metabolism. Both IDO2 and IDO1 can lead to the production of kynurenine highlighting their shared influence within this metabolic pathway.
The activity of IDO-2 plays a role in conditions like cancer and autoimmune diseases. In cancer its ability to suppress immune attack on tumors by depleting tryptophan and generating immunosuppressive metabolites allows tumor cells to escape immune surveillance. In autoimmune disorders like systemic lupus erythematosus altered tryptophan metabolism through IDO-2 involvement can affect disease progression. IDO-2 works alongside IDO1 within these pathological contexts influencing disease outcomes due to their shared enzymatic roles in immune modulation.