Abcam, ab214292, Anti-CRIM1 antibody

Size: 100µL
Rabbit Polyclonal CRIM1 antibody. Suitable for IHC-P and reacts with Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Mouse Cysteine-rich motor neuron 1 protein aa 850-950 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Mouse Cysteine-rich motor neuron 1 protein aa 850-950 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q9JLL0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CRIM1 also known as cysteine-rich motor neuron 1 protein has a molecular mass of around 110 kDa. As a transmembrane protein it localizes mainly to the endoplasmic reticulum. Researchers have detected its expression in various tissues including the retina kidneys brain and spinal cord. It contains a distinctive cysteine-rich motif and plays roles in cellular adhesion and growth factor regulation.
Biological function summary
The function of CRIM1 extends to the modulation of growth factor activity particularly by interacting with bone morphogenetic proteins (BMPs). This interaction suggests its potential involvement in developmental processes. Studies have indicated that CRIM1 might participate in forming protein complexes related to cell surface receptors influencing cell signaling pathways that govern growth and differentiation.
Pathways
CRIM1's involvement in BMP signaling and angiogenesis highlights its significance within these biological pathways. BMPs which are growth factors play a part in bone and cartilage development therefore CRIM1's regulatory action can affect these processes. Additionally CRIM1 interacts with proteins like noggin in the BMP pathway to modulate cellular responses to extracellular signals contributing to developmental and morphogenic outcomes.
CRIM1 links to congenital abnormalities and ocular disorders. Its known interaction with BMPs associates it with conditions like kidney dysplasia where the disruption of normal signaling can lead to organ malformations. In the context of eye development CRIM1's interaction with BMPs and noggin is important for retinal and lens development. Understanding CRIM1's role in these pathways could offer insights into therapeutic targets for congenital and degenerative diseases.