Abcam, ab214337, Anti-Flavivirus NS1 antibody [D/2/D6/B7]

Size: 1mL
Mouse Monoclonal POLG antibody. Suitable for WB, ICC/IF and reacts with Dengue virus 1, Dengue virus 2, Dengue virus 3, Dengue virus 4, Japanese encephalitis virus, West Nile virus, Zika virus samples. Cited in 9 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:D/2/D6/B7,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Dengue virus 1, Dengue virus 2, Dengue virus 3, Dengue virus 4, Japanese encephalitis virus, West Nile virus, Zika virus,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:This monoclonal antibody reacts with a conformational epitope present on DENV1, 2, 3, 4, ZIKV, JEV and WNV NS1.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.1% Proclin 150Constituents: 89.9% RPMI 1640, 10% Fetal Bovine Serum (FBS), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Flavivirus NS1 also known as non-structural protein 1 is a multifunctional viral protein with an approximate mass of 46 kDa. This protein is expressed by flaviviruses including dengue virus Zika virus and West Nile virus during viral replication. NS1 exists in different forms: monomeric dimeric and hexameric each playing specific roles in the viral life cycle. It is primarily found in infected host cells and secreted into the extracellular space where it interfaces with the host immune system.
Biological function summary
The non-structural protein 1 is a significant player in immune evasion. It assists in virus replication and modulation of the host's immune response. NS1 acts independently but also as part of a larger viral replication complex. By interacting with host cell proteins NS1 helps protect the virus from immune detection and supports its replication and spread within the host.
Pathways
Flavivirus NS1 plays an important role in immune modulation and endothelial function. It is intimately involved in the flavivirus replication pathway where it works alongside other viral non-structural proteins such as NS2B and NS3. It also impacts the Toll-like receptor signaling pathway which is critical for immune response to infections. NS1 bypasses host immune defenses by inhibiting complement activation which is a vital pro-inflammatory pathway.
Flavivirus NS1 is linked to dengue fever and Zika fever two significant human illnesses caused by flavivirus infection. In dengue fever NS1 is connected to vascular leakage and hemorrhagic symptoms. The interaction of NS1 with host proteins such as complement components further exacerbates disease severity. NS1 also plays a part in immune suppression during Zika infection influencing disease progression and outcomes.