Abcam, ab216471, IKK-16, IkappaB kinase inhibitor

Size: 5mg / 25mg
MW 520.1 Da. Potent, selective IκB kinase (IKK) inhibitor (IC 50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). Inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM. Inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis.
Key facts
CAS number:1186195-62-9,
Form:SolidSee storage information,
Molecular weight:520.1 Da,
Molecular formula:C28H30ClN5OS,
PubChem:56972179,
Nature:Synthetic,
Biochemical name:IKK 16 (hydrochloride),
Biological description:Potent, selective IκB kinase (IKK) inhibitor (IC50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). Inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM. Inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis.,
Canonical smiles:C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5.Cl,
InChi:InChI=1S/C28H29N5OS.ClH/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26;/h1-2,5-11,14,19,23H,3-4,12-13,15-18H2,(H,29,30,31);1H,
InChiKey:XFVDIVQCZWDBCW-UHFFFAOYSA-N,
IUPAC Name:[4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone;hydrochloride

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B1087 IKK16. B1087-25 is the same size as the 25 mg size of ab216471.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions