Abcam, ab217249, Alexa Fluor® 594 Anti-KAT8 / MYST1 / MOF antibody [EPR15803]

Size: 100µL
Rabbit Recombinant Monoclonal KAT8 / MYST1 / MOF antibody - conjugated to Alexa Fluor® 594. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15803,
Isotype:IgG,
Conjugation:Alexa Fluor® 594,
Excitation/Emission:Ex: 590nm, Em: 617nm,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The KAT8 protein also known as MYST1 or MOF functions as a histone acetyltransferase. It acetylates histone H4 at lysine 16 which is critical for chromatin structure and gene expression regulation. The molecular mass of KAT8 is approximately 55 kDa. This protein shows high expression in testis and is also present in other tissues. KAT8 is part of the MYST family of acetyltransferases sharing similarities with other MYST family proteins such as MOF protein.
Biological function summary
KAT8 plays an essential role in gene transcription regulation by forming part of a complex known as the MSL (Male-Specific Lethal) complex. This complex ensures dosage compensation in Drosophila by adjusting gene expression levels. KAT8 is vital for the maintenance of chromatin structure influencing gene activation and silencing across various biological systems. It interacts with several co-factors during transcription regulation further highlighting its functional significance in the epigenetic landscape.
Pathways
KAT8 engages in processes linked to chromatin modification and gene expression. Specifically it plays a significant role in the pathways of chromatin organization and transcriptional regulation by RNA polymerase II. The protein ENL participates in related pathways and interacts with KAT8 during transcription elongation. These interactions highlight KAT8's role in epigenetic regulation affecting multiple genes' transcription states.
KAT8 is associated with cancers and neurodevelopmental disorders. Aberrant expression or mutations in KAT8 have been observed in certain cancers making it a potential target for therapeutic intervention. In neurodevelopmental disorders changes in KAT8 acetyltransferase activity affect neuronal gene expression implicating it in disorders linked to cognitive deficits. Another protein TIP60 shows functional overlap with KAT8 in these conditions suggesting interconnected roles in disease pathogenesis.