Abcam, ab219857, Anti-FRMD8 antibody

Size: 100µL
Rabbit Polyclonal FRMD8 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FRMD8 aa 300-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FRMD8 aa 300-450. The exact immunogen used to generate this antibody is proprietary information.Q9BZ67

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FRMD8 also known as FERM domain-containing protein 8 has an approximate molecular mass of 76 kDa. This protein belongs to the FERM domain protein family characterized by having domains linked to cytoskeletal arrangements and membrane interactions. It expresses in various human tissues including the brain and the liver suggesting it performs functions necessary in multiple systems. It plays a structural or signaling role linked to its FERM domain capabilities.
Biological function summary
FRMD8 plays an essential role in cellular signaling and structure. It interacts with CYTH3 a protein significant for intracellular signaling and cytoskeletal dynamics. By interacting with proteins that regulate actin cytoskeleton FRMD8 helps maintain cellular architecture and motility. FRMD8 may also participate in protein complexes that influence cellular morphology and signaling cascades.
Pathways
FRMD8 engages in essential cellular pathways such as actin polymerization and Rho GTPase-mediated signaling. These pathways are important for cell shape migration and division. FRMD8 interacts with members of the Rho GTPase family like Rac1 further linking it to actin cytoskeletal rearrangements. In this way FRMD8 influences cellular behaviors that depend on cytoskeletal dynamics and intracellular communication.
FRMD8 associates with certain cancers and neurological conditions. In cancer it may interact with proteins like TKT that influence tumor cell metabolism and survival. Regarding neurological disorders the connection with proteins such as Alpha-synuclein links FRMD8 to synaptic function regulation and aggregation processes implicated in neurodegenerative diseases. This budding research area suggests that FRMD8 plays a significant role in disease biological mechanisms.