Abcam, ab219996, Anti-ESCO2 antibody

Size: 100µL
Rabbit Polyclonal ESCO2 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ESCO2 aa 300-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ESCO2 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.Q56NI9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ESCO2 also known as Establishment of Sister Chromatid Cohesion N-Acetyltransferase 2 is a protein with a mass of about 68 kDa. It is expressed widely across various human tissues with notable presence in proliferating cells. ESCO2 has a mechanistic role in the establishment of sister chromatid cohesion during the S phase of the cell cycle. It works by acetylating the cohesin subunit SMC3 which is essential for proper chromosome segregation during mitosis and meiosis.
Biological function summary
ESCO2 functions as a part of the chromosomal cohesion complex which is necessary for maintaining genome stability. The cohesion complex ensures that sister chromatids remain paired from DNA replication in S phase until anaphase. This complex requires synchronized action of cohesin proteins including STAG2 and RAD21 which work together with ESCO2 to ensure the fidelity of chromosomal transmission. By facilitating proper cohesion ESCO2 prevents aneuploidy which is often incompatible with cell viability.
Pathways
The protein ESCO2 interacts with the cell cycle regulatory pathways and chromosomal dynamics. Within these pathways ESCO2 cooperates with proteins like CDK1 and PLK1. These interactions help drive critical transitions between various phases of the cell cycle primarily assuring that chromosomes align correctly and segregate during mitosis. As ESCO2 modifies SMC3 via acetylation this modification is important for the action of the cohesin complex allowing it to perform its functions within the cell cycle control mechanisms.
ESCO2 has significant implications in Roberts Syndrome and certain cancers. Roberts Syndrome a developmental disorder results from mutations in the ESCO2 gene leading to defective cohesion. This defect impacts cell proliferation and differentiation contributing to the syndrome's phenotypic features. In cancer biology abnormal ESCO2 expression or function can result in genomic instability promoting oncogenesis. The interplay of ESCO2 with cohesin proteins like SMC3 and STAG2 highlights its critical role in maintaining chromosomal integrity essential for preventing disease.