Abcam, ab220093, Anti-CEP350 antibody

Size: 100µL
Rabbit Polyclonal CEP350 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CEP350 aa 1400-1550.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CEP350 aa 1400-1550. The exact immunogen used to generate this antibody is proprietary information.Q5VT06

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CEP350 also known as Centrosome-associated protein 350 is a large protein weighing approximately 350 kDa. It plays an important mechanical role in centrosome structure and function. Expressed mainly in tissues with high proliferative capacity CEP350 anchors microtubules to the centrosomes ensuring proper cell division. The protein localizes to the centrosome and is important for maintaining microtubule organization.
Biological function summary
CEP350 interacts with other centrosomal components to ensure proper spindle formation during mitosis. It is part of the pericentriolar material participating in complex formation with proteins such as ninein and AKAP450. These interactions stabilize the centrosome enabling effective microtubule nucleation and anchoring which are essential for cell cycle progression and cellular integrity.
Pathways
CEP350 contributes to the centrosome cycle and microtubule dynamics regulation. It plays a role in the interphase microtubule pathway coordinating with proteins like pericentrin to manage microtubule organization and stability. CEP350's interaction with the AKAP450 protein complex influences the microtubule-organizing center activity reflecting its role in essential cellular pathways.
CEP350 mutations or dysregulation link to microcephaly and retinal degeneration highlighting its role in neural development and visual function. Its association with pericentrin and AKAP450 can also impact ciliogenesis which when impaired may contribute to ciliopathies. Understanding CEP350's involvement in these conditions could lead to insights into their molecular mechanisms and potential therapeutic targets.