Abcam, ab220287, Anti-TRIM9 antibody

Size: 100µL
Rabbit Polyclonal TRIM9 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TRIM9 aa 100-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TRIM9 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.Q9C026

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRIM9 also known as Tripartite Motif Containing 9 is an E3 ubiquitin ligase with a mass of approximately 68 kDa. This protein adds ubiquitin to substrate proteins tagging them for proteasomal degradation or altering their activity. TRIM9 contains a RING domain B-box type zinc finger and coiled-coil region typical of the TRIM family proteins. It is widely expressed in the nervous system with high levels found in the brain highlighting its significance in neural processes.
Biological function summary
The TRIM9 protein regulates axon pathfinding and synapse formation influencing neural network development. TRIM9 forms complexes with other proteins to modulate cytoskeletal dynamics affecting neuron shape and connectivity. By interacting with proteins like DCC (Deleted in Colorectal Carcinoma) TRIM9 plays a role in guiding axons during neural circuit formation. This interaction is essential for creating proper neuronal connections and ensuring functional communication within the brain.
Pathways
TRIM9 emerges as an important regulator in the Netrin-1 signaling pathway critical for axonal guidance. This pathway involves interaction with DCC a receptor for Netrin-1 influencing axonal steering decisions. Additionally TRIM9 participates in the ubiquitination pathway affecting protein stability and cellular localization that modulates various signaling cascades within neurons. By manipulating these pathways TRIM9 assists in neural development and plasticity.
Alterations in TRIM9 expression or function correlate with neurological conditions such as schizophrenia and autism spectrum disorders. Dysfunctional TRIM9-mediated pathways might disrupt neural circuit development contributing to the cognitive and social impairments associated with these disorders. Other proteins like DCC also share connections with these disorders indicating a network of interactions where TRIM9 influences disease pathology.