Abcam, ab220386, Anti-ACAD9 antibody

Size: 100µL
Rabbit Polyclonal ACAD9 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Complex I assembly factor ACAD9, mitochondrial aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Complex I assembly factor ACAD9, mitochondrial aa 50-150. The exact immunogen used to generate this antibody is proprietary information.Q9H845

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein ACAD9 also known as acyl-CoA dehydrogenase family member 9 plays a role in mitochondrial fatty acid β-oxidation. It functions as an enzyme that catalyzes the initial step of this fatty acid metabolism process assisting in breaking down long-chain fatty acids. The mass of ACAD9 is approximately 71 kDa. This protein mainly expresses in tissues with high energy demands such as heart and skeletal muscle indicating its involvement in energy metabolism.
Biological function summary
ACAD9 participates in key enzymatic activities important for energy production. It forms part of a larger enzyme complex known as the electron transfer flavoprotein (ETF)-ubiquinone oxidoreductase complex which is essential for the transfer of electrons in the mitochondrial respiratory chain. This protein aids in converting stored fatty acids into acetyl-CoA which is then funneled into the Krebs cycle for further energy generation.
Pathways
ACAD9 is intricately linked to mitochondrial fatty acid oxidation and energy metabolism. It plays a central role in the β-oxidation pathway which is critical for converting fatty acids into usable energy. ACAD9 interacts with related proteins such as electron transfer flavoprotein (ETF) and ETF-ubiquinone oxidoreductase facilitating the transfer of electrons derived from fatty acid metabolism into the respiratory chain thereby producing ATP efficiently.
Mutations or deficiencies in ACAD9 can lead to fatty acid oxidation disorders such as multiple acyl-CoA dehydrogenase deficiency. These conditions manifest with severe metabolic myopathies and cardiomyopathies. ACAD9's role connects it to other proteins involved in mitochondrial function such as ETF which also associates with similar disorders. Understanding ACAD9's function aids in diagnosing and developing therapeutic approaches for these metabolic conditions.