Abcam, ab220390, Anti-HOXB2 antibody

Size: 100µL
Rabbit Polyclonal HOXB2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HOXB2 aa 50-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HOXB2 aa 50-100. The exact immunogen used to generate this antibody is proprietary information.P14652

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The HOXB2 protein also known as Homeobox B2 plays an important role in gene regulation during development. This protein belongs to the homeobox family which is characterized by the presence of a 60 amino acid residue helix-turn-helix motif that binds DNA. HOXB2 has a molecular mass of approximately 30 kDa. It is notably expressed in a variety of tissues including the central nervous system and axial skeleton where it contributes to the spatial specificity of cell differentiation.
Biological function summary
HOXB2 influences the patterning of structures along the anterior-posterior axis in embryonic development. It does not function as a solitary protein but operates as part of a larger homeodomain protein complex. This protein participates in the regulation of genes responsible for morphogenesis. Its expression levels directly affect the identity and position of structures like the vertebrates and cranial nerves during early fetal development.
Pathways
HOXB2 integrates its function within the retinoic acid signaling cascade which plays a pivotal role in embryogenesis. It connects with other members of the HOX family creating an orchestrated network of gene regulation that ensures proper spatial development. HOXB2's interaction with retinoic acid receptors enables the transmission of signals that dictate pattern formation and differentiation processes across various tissues.
Mutations or misregulation of HOXB2 have implications in congenital malformations and specific cancers such as leukemia. HOXB2 dysregulation in acute myeloid leukemia suggests its involvement in pathways alongside key proteins like HOXA9 and MEIS1. Such connections underline the protein’s influence in maintaining cellular identity and proliferation balance making HOXB2 a potential target for therapeutic strategies in developmental disorders and hematological malignancies.