Abcam, ab220745, Anti-PDGFRL antibody

Size: 100µL
Rabbit Polyclonal PDGFRL antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PDGFRL aa 200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PDGFRL aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q15198

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PDGFRL known as Platelet-Derived Growth Factor Receptor-like protein has a mass of approximately 42 kDa. It is not a typical receptor but it resembles PDGF receptors at the molecular level. PDGFRL is expressed widely in various tissues with significant presence in normal cells like fibroblasts and endothelial cells. Unlike classic PDGF receptors that signal from the cell membrane PDGFRL is more involved in cytoplasmic processes.
Biological function summary
The function of PDGFRL remains less understood compared to other PDGF family members. Its structure suggests involvement in modulating PDGF signaling without intrinsic kinase activity. PDGFRL interactions might not form standard receptor-ligand complexes but rather influence PDGF receptor pathways indirectly. Research implies it plays a role in body development and cell growth by influencing PDGF receptor interactions.
Pathways
Studies point out PDGFRL’s involvement in cellular processes such as cell proliferation and tissue regeneration. PDGF signaling pathways where PDGFRL can act involve MAPK/ERK and PI3K/AKT both essential for various cellular responses. PDGFRL may interact with other proteins in these pathways affecting the overall signaling cascade without activating it directly serving more as a modulatory molecule.
Researchers have associated PDGFRL with certain cancers such as gastric carcinoma and meningiomas potentially due to its role in regulating cell growth. Changes in PDGFRL expression or function might alter PDGF-A and PDGF-B mediated pathways contributing to abnormal cell proliferation. PDGFRL's relation to these conditions highlights its importance as a potential marker for diagnosis or a target for therapeutic strategies.