Abcam, ab220856, Anti-HOXD1 antibody

Size: 100µL
Rabbit Polyclonal HOXD1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HOXD1 aa 250 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HOXD1 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9GZZ0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HOXD1 also known as Homeobox D1 is a transcription factor that plays a role in regulating gene expression. This protein has a mass of approximately 32 kDa. HOXD1 is part of the homeobox gene family which encodes transcription factors characterized by a specific sequence that binds DNA. HOXD1 shows expression in various tissues including the central nervous system and limbs during development. Its expression patterns suggest a role in the spatial and temporal regulation of developmental processes.
Biological function summary
HOXD1 contributes to the regulation of morphogenic development influencing the body layout along the anterior-posterior axis. It is not typically shown to be part of any larger protein complexes but interacts with other transcription factors to influence gene networks. During embryonic development HOXD1 orchestrates the activation and repression of target genes guiding proper morphogenesis and differentiation. This role is significant in setting positional identity and patterning of tissues.
Pathways
The HOXD1 protein participates in key developmental signaling pathways notably the Wnt signaling pathway. Wnt signaling affects cell proliferation polarity and migration making it critical during embryogenesis. HOXD1 collaborates with other homeobox genes like HOXA and HOXB clusters to ensure precise developmental patterning. The interactions among these homeobox proteins promote coordinated regulation of gene expression necessary for orderly development.
Alterations in HOXD1 expression have been linked to developmental disorders and certain cancers. Abnormal expression of HOXD1 may contribute to conditions such as synpolydactyly which affects limb development. Studies also suggest its potential involvement in various carcinomas due to its role in cell differentiation and proliferation. HOXD1's connections with other regulatory proteins like those in homeobox family suggest its mutation or dysregulation could influence similar associated disorders.