Abcam, ab221099, Anti-IRF2BPL antibody

Size: 100µL
Rabbit Polyclonal IRF2BPL antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human IRF2BPL aa 500-600.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human IRF2BPL aa 500-600. The exact immunogen used to generate this antibody is proprietary information.Q9H1B7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IRF2BPL also known as Interferon Regulatory Factor 2 Binding Protein Like is a protein with a mass of roughly 86 kDa. This protein is expressed widely in various tissues with notable expression in the central nervous system. Mechanically IRF2BPL functions as a transcriptional regulator. It interacts with DNA influencing the transcription of genes that play roles in cellular processes including cell growth and immune responses.
Biological function summary
IRF2BPL's regulatory activities influence neurodevelopment and neuroprotection. It does not typically form part of larger protein complexes. Instead it modulates gene expression linked to neuronal survival and maturation. The protein involvement in the transcription of genes that affect neuronal function suggests its critical roles in maintaining nervous system health and function.
Pathways
IRF2BPL is intricately involved in the neuronal signaling pathway. It acts alongside proteins like IRF2 where they collectively impact the transcriptional regulation of genes that participate in neuronal differentiation and development. Links with the mTOR signaling pathway also exist with implications for axonal growth and neuroprotection indicating that IRF2BPL bridges cellular growth pathways with specific neuronal processes.
Malfunctions in IRF2BPL are linked to neurodevelopmental disorders such as NEDAMSS (Neurodevelopmental Disorder with Regression Abnormal Movements and Seizures). Mutations in the IRF2BPL gene can lead to severe clinical symptoms including intellectual disability and epilepsy. Connections with proteins like MECP2 further support its role in neurological conditions highlighting the essential nature of IRF2BPL in maintaining normal neural functions.