Abcam, ab221101, Anti-HOXD3 antibody

Size: 100µL
Rabbit Polyclonal HOXD3 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HOXD3 aa 350 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HOXD3 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P31249

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Homeobox protein D3 (HOXD3) is a transcription factor belonging to the homeobox gene family and plays a role in regulating gene expression during development. HOXD3 is also known by the alternative name HOX4A. The protein has a molecular mass of approximately 34 kDa. It is expressed in several tissues with higher levels observed in the developing limbs spinal cord and brain. HOXD3 binds to specific DNA sequences controlling the transcription of genes important for the body's patterning during embryogenesis.
Biological function summary
HOXD3 influences cellular processes like differentiation and migration by regulating target gene expression. It is not part of a complex but interacts with other transcription factors and co-regulators to execute its functions. HOXD3 plays a role in angiogenesis helping to form new blood vessels during development and in response to tissue damage. This regulatory function impacts the vascularization of tissues and the delivery of nutrients and oxygen which are critical for proper tissue growth and repair.
Pathways
HOXD3 engages in the signaling processes that govern cellular proliferation and migration. The protein is an integral component of the retinoic acid signaling pathway contributing to cellular differentiation. It also interacts with proteins like VEGF to affect angiogenic pathways which involve the growth of new blood vessels from pre-existing vasculature. These pathways are essential not only for developmental processes but also for healing after injury.
HOXD3 shows connections to cancer progression particularly in several carcinomas due to its role in promoting cell migration and invasion. Elevated HOXD3 expression has been linked to the increased metastatic potential of tumor cells. Furthermore aberrations in the protein's regulation may relate to developmental disorders affecting limb formation and neurological functions. HOXD3 interacts with proteins such as VEGF highlighting its involvement in pathological conditions characterized by abnormal angiogenesis and tissue growth.