Abcam, ab221353, Anti-UNCX antibody

Size: 100µL
Rabbit Polyclonal UNCX antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human UNCX aa 150-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human UNCX aa 150-250. The exact immunogen used to generate this antibody is proprietary information.A6NJT0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UNCX also called UNC homeobox is a protein that functions as a transcription factor. It belongs to the HOX family and has a molecular mass of around 62 kDa. UNCX is mainly expressed in the central nervous system especially during embryonic development and in the neural and mesodermal tissues. Its expression is also observed in adult tissues although at lower levels. The protein plays key roles in developmental processes through its action as a transcription factor influencing gene expression.
Biological function summary
UNCX regulates the development of vertebrate axial skeletons and the neuromuscular system. It acts in embryogenesis ensuring proper vertebrae formation and influencing neurogenesis. UNCX functions as part of a transcriptional regulatory complex where it interacts with other proteins to control the transcription of specific target genes. These regulatory activities demonstrate its involvement in critical developmental stages and neural patterning.
Pathways
The transcription activities of UNCX influence the Notch signaling pathway and the Wnt signaling pathway. These pathways are essential in maintaining cellular differentiation and proliferation during development. UNCX interacts with proteins such as Notch receptors and β-catenin which are key components of these pathways. By coordinating with these proteins UNCX contributes to the fine-tuning of transcriptional responses during developmental processes.
Mutations or dysregulation of UNCX relate to congenital vertebral malformations and several neurodevelopmental disorders. For instance alterations in UNCX expression may contribute to defects in vertebral segmentation leading to disorders like scoliosis. Additionally aberrant activity of UNCX has associations with neural tube defects due to its ties with transcription factors like Pax6. Understanding its roles in such conditions may provide insights into potential therapeutic targets.