Abcam, ab221996, Anti-SHC4/SHCD antibody

Size: 100µL
Rabbit Polyclonal SHC4/SHCD antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SHC4 aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SHC4 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.Q6S5L8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SHC4 also known as SHCD is a member of the SHC (Src Homology 2 domain-containing) family and plays an important role in intracellular signaling. The protein has a molecular mass of approximately 72 kDa. SHC4 mainly localizes in the cytoplasm and can translocate to the membrane where it participates in signaling activities. Its expression occurs widely across different tissues but it shows a particularly strong expression in the nervous system indicating a potential role in neural processes.
Biological function summary
SHC4 serves as an adaptor protein that connects activated receptors to downstream signaling pathways. It can associate with various signaling complexes helping to mediate responses to extracellular stimuli. SHC4 transmits signals from receptors like receptor tyrosine kinases (RTKs) and plays a part in cellular functions such as proliferation and differentiation. These attributes highlight its involvement in complex networks that control cellular responses.
Pathways
SHC4 participates in signaling cascades like the MAPK/ERK and PI3K/AKT pathways. It interacts with proteins such as GRB2 which transmits signals from activated RTKs to the Ras protein ultimately influencing cell fate decisions. These pathways are critical for regulating cell cycle progression cellular growth and metabolism demonstrating SHC4's integral function in these processes.
SHC4 associates with conditions impacting the nervous system including neurodevelopmental disorders. Its altered signaling capability may relate to aberrant neural development affecting processes stabilized by SHC4. Moreover SHC4 has been studied in cancer where dysregulation of associated pathways like MAPK/ERK plays a significant role. Its interaction with proteins such as RAS which can act as oncogenes when mutated marks SHC4 as an important protein in oncology research.