Abcam, ab222206, Anti-FAN1 antibody

Size: 100µL
Rabbit Polyclonal FAN1 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FAN1 aa 900 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FAN1 aa 900 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9Y2M0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FAN1 also known as Fanconi-associated nuclease 1 is a protein implicated in DNA repair processes. The protein has a molecular mass of approximately 101 kDa. FAN1 can be found in various tissues with enriched expression in testis thymus and liver. It operates as a nuclease engaging in processes to remove DNA crosslinks maintaining the integrity of genetic material.
Biological function summary
FAN1 plays a significant role in the repair of interstrand cross-links within DNA. FAN1 acts as part of a complex that detects and processes these cross-links aiding in cell survival by preventing genome instability. It connects with the Fanconi anemia pathway proteins which include FANCD2 and FANCI to promote the repair process. The function of FAN1 is critical in preserving cellular health under conditions that could potentially damage DNA.
Pathways
FAN1 exists prominently in the DNA damage response and the Fanconi anemia pathway. It interacts closely with proteins such as MLH1 tying into a broader network of repair mechanisms. These pathways are essential for cellular resistance to various stressors that threaten genomic stability. FAN1's precise involvement ensures cells can effectively manage DNA damage contributing to proper functioning of genetic repair networks.
FAN1 displays connections with two significant conditions: Fanconi anemia and colorectal cancer. Mutations or deficiencies in FAN1 can lead to increased susceptibility to genomic instability disorders like Fanconi anemia. The protein also associates with proteins like PMS2 and MLH1 which when mutated contribute to colorectal cancer. Understanding FAN1's role offers insight into therapeutic targets and genetic predispositions related to these conditions.