Abcam, ab222793, Anti-ISPD antibody

Size: 50µL
Rabbit Polyclonal ISPD antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CRPPA aa 1-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CRPPA aa 1-300. The exact immunogen used to generate this antibody is proprietary information.A4D126

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ISPD also known as isoprenoid synthase domain-containing protein functions as an important enzyme in the cellular biosynthesis process. It has a molecular mass of approximately 46 kDa. This protein plays a central role in the formation of dolichol phosphate sugars which are essential for the glycosylation of proteins. The ISPD gene expresses highly in tissues such as muscle and heart where glycosylation processes are vital for normal function.
Biological function summary
ISPD contributes to the synthesis of critical isoprenoid compounds. ISPD does not operate alone it functions as part of a larger machinery that ensures proper protein modification which allows correct cellular location and function of glycoproteins. In this setting ISPD is important because it influences how cells manage structural stability and communication between cellular environments.
Pathways
ISPD participates significantly in the dolichol phosphate biosynthesis pathway. This pathway is important for enabling protein glycosylation in the endoplasmic reticulum. ISPD interacts with DPM1 an important protein in the dolichol cycle to effectively transport glycan precursors across the membrane. ISPD also impacts the protein N-linked glycosylation pathway where it assists in modifying proteins for functional diversity and stability.
ISPD has a strong connection to a group of muscular dystrophies notably Walker-Warburg Syndrome. This syndrome is characterized by severe muscular and ocular abnormalities due to defects in O-mannosyl glycan synthesis. Mutations in the ISPD gene can impair normal function leading to these pathologies. Furthermore its interactions with proteins like POMT1 emphasize its pivotal role in muscle integrity as disruptions in these associations can contribute to disease progression.