Abcam, ab222805, Anti-ARHGAP10 antibody

Size: 50µL
Rabbit Polyclonal ARHGAP10 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ARHGAP10 aa 500-750.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ARHGAP10 aa 500-750. The exact immunogen used to generate this antibody is proprietary information.A1A4S6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ARHGAP10 also known as Rho GTPase activating protein 10 is involved in regulating the activity of Rho-type GTPases. This protein acts as a GTPase-activating protein (GAP) promoting the inactivation of RhoA Rac1 and Cdc42 molecules. ARHGAP10 weighs approximately 88 kDa and shows high expression levels in the brain and the lymphoid tissues. Its activity influences cellular mechanisms through the modulation of the actin cytoskeleton affecting various cellular processes such as movement and morphology.
Biological function summary
The function of ARHGAP10 involves the modulation of cytoskeletal dynamics linking it directly to processes of cellular movement and structure. It participates as part of a complex network that influences cell signaling and cytoskeletal rearrangement. Through its interaction with Rho family GTPases ARHGAP10 plays a significant role in altering cellular adhesion and migration essential processes in development and tissue maintenance.
Pathways
ARHGAP10 is prominently involved in the Rho GTPase signaling pathway influencing actin cytoskeleton organization. It interacts with proteins like ROCK1 and ROCK2 affecting contraction in smooth muscle cells. Another critical pathway involving ARHGAP10 includes the Wnt signaling pathway where it influences cellular proliferation and differentiation impacting developmental processes and cellular responses to external signals.
ARHGAP10 has a connection to cancer particularly through its role in cellular migration and invasion. Abnormal regulation of ARHGAP10 expression or function could lead to dysregulated cell movement contributing to metastasis. Furthermore ARHGAP10's involvement in the Rho GTPase pathway links it to neurodevelopmental disorders as it affects the organization of neural structures. In cancer proteins like Rac1 and Cdc42 which interact with ARHGAP10 are often implicated in the modulation of tumor progression and metastasis.