Abcam, ab222814, Anti-SH2D1B antibody

Size: 50µL
Rabbit Polyclonal SH2D1B antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SH2D1B aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SH2D1B aa 1-100. The exact immunogen used to generate this antibody is proprietary information.O14796

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SH2D1B also known as EAT-2 is an adaptor protein that has a significant role in immune cell signaling. It is about 15 kDa in size and contains a single SH2 domain which allows it to interact with phosphorylated tyrosine-containing proteins. SH2D1B is mainly expressed in natural killer (NK) cells and some T-cell populations. In these cells SH2D1B modulates signaling pathways by interacting with various receptors and other signaling proteins affecting cellular responses.
Biological function summary
SH2D1B influences immune cell activation and effector functions. It is part of a signaling complex that modulates the activity of NK cells and some T-cells influencing processes like cytotoxicity and cytokine production. By participating in this complex SH2D1B plays a role in regulating immune responses affecting conditions ranging from viral infections to cancer surveillance where adaptive immunity is modified.
Pathways
SH2D1B is involved in the regulation of the SLAM family receptor signaling pathway which is vital for the activation and function of NK cells. It interacts closely with other proteins in this pathway such as SAP (SLAM-associated protein) to influence signaling cascades that determine cell fate and activity. SH2D1B also participates in the NF-kB signaling pathway further affecting immune responses through modulation of gene expression involved in cell survival and differentiation.
SH2D1B has associations with immune system dysfunctions such as X-linked lymphoproliferative syndrome (XLP). This disorder involves unregulated immune responses and is linked to an overactive or misregulated SLAM receptor signaling where SH2D1B collaborates with SAP. Additionally variations in SH2D1B expression or function have potential links to autoimmune diseases due to its role in regulatory pathways of immune activation and suppression.