Abcam, ab223470, Anti-GLUT9 antibody

Size: 50µL
Rabbit Polyclonal GLUT9 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 9 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC2A9 aa 450 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLC2A9 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9NRM0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GLUT9 also known as SLC2A9 functions as a facilitative glucose transporter with a molecular weight of about 57 kDa. It is highly expressed in the kidneys and liver with lower levels of expression in other tissues such as the placenta and heart. GLUT9 facilitates the transport of uric acid glucose and fructose across the cell membrane playing an important role in cellular energy balance and metabolic processes.
Biological function summary
In the human body this protein influences urate homeostasis by managing uric acid levels in the blood. GLUT9 operates as a homomeric protein meaning it forms a functional unit by itself rather than needing to associate with other proteins to function. It significantly affects renal reabsorption processes regulating the excretion and reabsorption of urate in the kidneys. By controlling these uric acid levels it plays an important part in preventing hyperuricemia and related complications.
Pathways
GLUT9 contributes mainly to carbohydrate metabolism and urate transport pathways. Its role within the urate transport pathway links it to various other urate transporter proteins such as URAT1 which also participates in the regulation of uric acid excretion. In glucose metabolism GLUT9 works alongside other glucose transporters to maintain glucose levels linking it indirectly to pathways involving insulin response.
Elevated GLUT9 activity associates closely with conditions like gout and hyperuricemia. Due to its role in uric acid transport any dysfunction in GLUT9 can lead to increased serum uric acid contributing to gout development. Furthermore the interaction between GLUT9 and correlating proteins such as ABCG2 influences uric acid excretion processes connecting it to the pathological mechanisms underpinning these disorders. Researchers focus on these interactions to develop potential therapeutic strategies to manage related conditions effectively.