Abcam, ab223721, Anti-SELS antibody

Size: 100µL
Rabbit Polyclonal SELS antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SELENOS aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SELENOS aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9BQE4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Selenoprotein S (SELS) also known as VIMP has a significant role in promoting the degradation of misfolded proteins in the endoplasmic reticulum (ER). It is part of the selenoprotein family incorporating selenium in the form of selenocysteine. The protein has a molecular mass of approximately 22 kDa. SELS localizes to the membrane of the ER and is expressed broadly across various tissues showing higher levels in liver and muscle.
Biological function summary
SELS participates actively in the regulation of ER stress response and inflammation. It functions as an important component of the ER-associated degradation (ERAD) pathway mediating the extraction and degradation of faulty proteins. This activity stems from its ability to interact with ubiquitin ligase complexes aiding in protein quality control. Its role is integral for maintaining cellular homeostasis and preventing accumulation of protein aggregates.
Pathways
SELS engages profoundly with the oxidative stress and inflammatory pathways. It modulates the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) signaling pathway which influences inflammation and immune responses. SELS also interfaces with other proteins like p97/VCP and Derlin-1 which assist in the ERAD process demonstrating its connectivity within cellular stress response pathways.
SELS has connections to metabolic syndrome and inflammatory diseases. Altered expression levels of SELS are linked to the development of type 2 diabetes and obesity by influencing inflammatory mechanisms. SELS interacts with inflammatory cytokines like tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) highlighting its relevance in modulating immune responses linked to these conditions.