Abcam, ab224467, Anti-MRPL37 antibody

Size: 100µL
Rabbit Polyclonal MRPL37 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MRPL37 aa 100-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MRPL37 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.Q9BZE1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The target MRPL37 also known as Mitochondrial Ribosomal Protein L37 plays a role in protein synthesis within the mitochondria. With a molecular mass of approximately 47 kDa MRPL37 is a component of the large subunit in mitochondrial ribosomes. It is expressed in a range of tissues reflecting its essential role in cellular respiration and metabolism. This protein localizes to the mitochondrial matrix hinting at its critical function within the organelle's unique environment.
Biological function summary
MRPL37 helps in forming mitochondrial ribosomes which consist of a conglomerate of proteins and rRNA unique from their cytoplasmic counterparts. It is a component of the 39S large mitochondrial ribosomal subunit. MRPL37’s integration into this complex highlights its role in the translation of mitochondrial DNA-encoded proteins. These proteins are primarily integral to the oxidative phosphorylation pathway linking MRPL37 to energy production within cells.
Pathways
MRPL37 participates in mitochondrial translation and is essential for the oxidative phosphorylation pathway which is important for ATP synthesis. This pathway is a central component of cellular energy production involving related proteins such as ATP synthase and cytochrome c oxidase. In this context MRPL37 ensures the synthesis of key mitochondrial proteins required for the electron transport chain's proper operation.
Deficiencies or mutations in MRPL37 correlate with mitochondrial disorders often presenting as myopathies or neurodegenerative diseases due to impaired energy production. Additionally there is a link between MRPL37 and Leigh syndrome a severe neurological disorder. Such associations underline the necessity of proper mitochondrial function with MRPL37 interacting with other mitochondrial-related proteins such as NDUFAF2 in disease pathogenesis.