Abcam, ab224570, Anti-COX20 antibody - C-terminal

Size: 100µL
Rabbit Polyclonal COX20 antibody. C-terminal. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human COX20 aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human COX20 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q5RI15

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
COX20 also known as FAM36A is a mitochondrial protein with a mass of around 11 kDa. COX20 helps the assembly and stability of cytochrome c oxidase (COX) the terminal enzyme of the mitochondrial respiratory chain. Researchers found COX20 widely expressed in tissues with high metabolic rates including the heart skeletal muscle and brain. It functions by acting as a chaperone specifically aiding the insertion of COX2 into the mitochondrial inner membrane.
Biological function summary
COX20 facilitates complex IV's assembly by ensuring proper incorporation of subunits into the holoenzyme. This process is important for efficient mitochondrial oxidative phosphorylation which produces ATP. COX20 is part of a mitochondrial protein complex that incorporates the COX2 subunit into the cytochrome c oxidase complex. Disturbances in COX20's function can lead to defects in energy production highlighting its role in cellular metabolism.
Pathways
Scientists have positioned COX20 in the electron transport chain where it assists cytochrome c oxidase integration an important step in cellular respiration. COX20 interacts with other proteins like COX15 and SURF1 which are also essential components in the electron transport pathway coordinating the assembly of the cytochrome oxidase complex. Efficient pathway function ensures energy metabolism in cells affecting nutrient utilization and energy balance.
Abnormalities in COX20 have associations with mitochondrial disorders particularly COX deficiency which can lead to various neuromuscular diseases. Research shows that defective COX20 impacts neurological and muscular functions revealing links to conditions such as Leigh syndrome and encephalomyopathy. Alongside proteins like SCO1 impaired COX20 can alter copper transportation and incorporation within cytochrome c oxidase pointing to its role in disease processes.