Abcam, ab225556, Anti-FAF1 antibody

Size: 100µL
Rabbit Polyclonal FAF1 antibody. Suitable for IHC-P, IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human FAF1 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FAF1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9UNN5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab225556 was affinity purified using an epitope specific to FAF1 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FAF1 also known as FAS-associated factor 1 functions mechanically by interacting with the FAS receptor to modulate apoptotic processes. It has a molecular weight of approximately 74 kDa. This protein can be found in various tissues with higher expression in the brain liver and kidney. The expression suggests its diverse roles in cellular processes across different organ systems.
Biological function summary
FAF1 interacts with ubiquitin-like modifiers to influence the cellular response to stress. It is part of the death-inducing signaling complex (DISC) where it contributes to the regulation of apoptosis. In addition to apoptosis FAF1 plays a role in regulating protein degradation processes connecting its function to proteostasis in cells.
Pathways
FAF1 takes part in significant cellular processes including the apoptotic signaling pathway and the NF-kB signaling pathway. In these pathways it interacts with FAS and NF-kB proteins contributing to cell death and inflammatory responses respectively. The influence on these pathways showcases its role in maintaining balance between cell survival and cell death.
FAF1 displays connections to neurodegenerative diseases and cancers. It has been implicated in the pathogenesis of Parkinson's disease where its dysregulation can affect neuronal survival. Furthermore its interaction with FAS in the apoptosis pathway links FAF1 to certain types of cancers where apoptotic failure results in uncontrolled cell growth. Understanding FAF1's role is essential for developing therapeutic strategies targeting these pathways and associated conditions.