Abcam, ab225915, Anti-OS9 antibody

Size: 50µL
Rabbit Polyclonal OS9 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Protein OS-9 aa 200-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Protein OS-9 aa 200-450. The exact immunogen used to generate this antibody is proprietary information.Q13438

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OS9 also known as osteosarcoma amplified 9 protein has a molecular mass of approximately 84 kDa. The protein primarily locates in the endoplasmic reticulum (ER). OS9 functions as an ER-associated protein that plays an important role in the recognition and targeting of misfolded glycoproteins for degradation through the ER-associated degradation (ERAD) pathway. It assembles as part of the ERAD machinery through interactions with glycoproteins via its mannose 6-phosphate receptor homology (MRH) domain directly influencing the fate of proteins that fail proper folding.
Biological function summary
OS9 plays an important role in protein quality control within the cell. It forms part of a complex that detects and binds misfolded glycoproteins therefore marking them for transport to the proteasome for degradation. This function aids in maintaining cellular homeostasis by preventing the accumulation of defective proteins that can lead to cellular stress and dysfunction. The protein works in coordination with other ER chaperones and components such as SEL1L and HERPUD1 facilitating efficient substrate delivery to the degradation pathway.
Pathways
OS9 integrates into the ERAD pathway which is important for managing the protein folding load within the ER. This process is essential in managing and mitigating ER stress linked to the unfolded protein response (UPR). In particular OS9 interacts with ER mannosyl-oligosaccharide 12-alpha-mannosidase (MAN1B1) to trim mannose a vital step in determining protein fate within this pathway. Additionally OS9 links with proteins such as XBP1 helping regulate cellular stress responses.
OS9 has implications in neurodegenerative diseases and cancer. Misregulation or mutations affecting its function can contribute to diseases characterized by protein misfolding such as Alzheimer's disease where it might interact with other proteins involved in amyloid precursor protein (APP) processing. Additionally in the context of cancer overexpression correlates with tumor progression in certain cancers as it may influence pathways involving HERPUD1 affecting cell survival and proliferation under stress conditions.