Abcam, ab227699, Anti-TRBC1 antibody [SP305]

Size: 100µL / 500µL / 1mL
Rabbit Recombinant Monoclonal T Cell Receptor antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:SP305,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Purification notes-Purified from TCS by Protein A/G., Storage buffer-pH: 7.2 - 7.4Preservative: 0.1% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRBC1 also known as T-Cell Receptor Beta Constant 1 is involved in the formation of the T-cell receptor complex. It has a molecular mass of around 18 kDa. This protein component is prominently expressed on the surface of T lymphocytes important for mediating immune responses. TRBC1 is a part of the TCR constant region playing a significant role in antigen recognition through its interaction with antigen-presenting cells.
Biological function summary
TRBC1 contributes to the immune system’s mechanism by helping identify foreign invaders in the body. It works as an integral part of the T-cell receptor (TCR) complex facilitating T-cell activation and signaling. The complex formation includes variable and constant regions with TRBC1 as a fixed part of the constant region ensuring the proper receptor structure for effective recognition. TCR assembly is important for T cells to detect specific antigens.
Pathways
TRBC1 participates in the adaptive immune response and T-cell receptor signaling pathway. Interacting proteins such as CD3 and ZAP70 help transmit signals initiated at the surface by antigen recognition leading to downstream effects such as cell proliferation and cytokine release. TRBC1’s involvement in these pathways ensures the T cells' ability to respond to invading pathogens and maintain immune surveillance.
TRBC1 has been implicated in conditions like autoimmune diseases and certain cancers such as T-cell lymphomas. Its interaction with proteins like CD3 impacts these disorders by amplifying or misdirecting immune responses. Aberrant TRBC1 expression or mutations can disrupt normal immune functions triggering disease development or progression. Understanding TRBC1's role in these contexts helps in developing targeted therapies and diagnostic tools.