Abcam, ab228701, Anti-TUBA4A antibody - Loading Control

Size: 100µL
Rabbit Polyclonal Alpha-tubulin 4 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Rat, Drosophila melanogaster, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TUBA4A.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human, Drosophila melanogaster,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TUBA4A. The exact immunogen used to generate this antibody is proprietary information.P68366

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TUBA4A also known as Tubulin Alpha 4A helps in the polymerization of microtubules acting as a core component of the cytoskeleton. It weighs approximately 50 kDa. This protein is expressed in various tissues including the nervous system and muscles. It plays a role in maintaining cellular structure and functions in cellular transport and division.
Biological function summary
Tubulin Alpha 4A is involved in the dynamic assembly and disassembly of microtubules contributing to cell shape and intracellular transport. It forms part of the microtubule complex and interacts with other tubulin isoforms to provide stability and flexibility to microtubule structures. This protein is essential for dividing cells as it supports the mitotic spindle's function during cell division.
Pathways
The TUBA4A protein actively participates in cytoskeleton regulation and signal transduction. It is part of the MAPK signaling pathway important for cell division and differentiation. Components like MAP kinases and related tubulins work together within these pathways to mediate cellular responses to various stimuli facilitating critical cell functions and adaptability.
TUBA4A has associations with neurodegenerative conditions and cancers. Mutations in TUBA4A have a link to amyotrophic lateral sclerosis (ALS) where disruptions in microtubule function lead to neuronal damage. Additionally aberrant expression of TUBA4A may contribute to tumor progression where interactions with proteins like beta-tubulin disrupt cellular adhesion and division mechanisms.