Abcam, ab228897, Anti-CTF/NFIA antibody

Size: 100µL
Rabbit Polyclonal NFIA antibody. Suitable for WB, IHC-P, ICC/IF, IHC-Fr and reacts with Human, Mouse, Rat samples. Cited in 12 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NFIA.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WB, IHC-Fr, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NFIA. The exact immunogen used to generate this antibody is proprietary information.Q12857

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The transcription factor CTF/NFIA also known simply as NFIA plays a significant role in gene regulation. It has a molecular weight of approximately 55 kDa. CTF/NFIA is expressed in various tissues with a higher abundance in the central nervous system particularly during development. It binds to specific DNA sequences influencing the transcription of target genes essential for developmental processes and cellular differentiation.
Biological function summary
CTF/NFIA participates in several cellular processes by forming part of a complex that regulates transcription. This complex influences the expression of genes involved in neurodevelopment and gliogenesis. CTF/NFIA acts as a major regulator controlling genes important for the proper formation of brain structure and function. Its ability to modulate gene expression allows it to act as a mediator for cellular environments that require precise genetic control.
Pathways
The protein integrates a network involving the Wnt signaling pathway and the Hedgehog signaling pathway. These pathways are fundamental in maintaining proper cellular growth division and differentiation. In the Wnt signaling pathway CTF/NFIA interacts with the β-catenin complex to control the expression of genes related to cell fate decisions. Similarly within the Hedgehog signaling pathway CTF/NFIA helps in modulating transcriptional responses to developmental cues.
CTF/NFIA has significant implications for brain-related conditions including hydrocephalus and intellectual disabilities. Mutations or dysregulation of NFIA are linked to structural brain malformations that can have severe impacts. Additionally CTF/NFIA interacts with proteins like GLI1 in the context of disease further highlighting its role in signal transduction pathways that when disrupted contribute to these disorders.