Abcam, ab228926, Anti-ZNF207/BUGZ antibody

Size: 100µL
Rabbit Polyclonal ZNF207/BUGZ antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF207.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZNF207. The exact immunogen used to generate this antibody is proprietary information.O43670

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF207 also known as BUGZ functions as a zinc finger protein involved in regulating microtubule dynamics. The molecular weight of ZNF207/BUGZ is around 90 kDa. It finds expression widely in human tissues but shows a higher abundance in cells actively undergoing division. This protein assists in stabilizing spindle microtubules by promoting the proper assembly of tubulin subunits which is essential during mitosis. Additionally ZNF207 appears significant in maintaining genomic stability acting as a safeguard for accurate chromosome segregation.
Biological function summary
ZNF207/BUGZ plays a critical role in mitotic progression and spindle stability. This protein integrates into the spindle assembly checkpoint complex ensuring fidelity during mitotic chromosome segregation. By interacting with BUB3 a spindle checkpoint protein ZNF207/BUGZ facilitates the recruitment and localization of key components to the mitotic spindle during cell division. Furthermore its involvement in thymocyte differentiation highlights its importance in immune cell development.
Pathways
The mechanism of ZNF207/BUGZ intersects with the cell cycle regulatory network and the microtubule organization pathway. In the cell cycle pathway it influences the control of mitosis in sync with proteins like MAD2 and BUBR1 which are important for checkpoint signaling and prevention of premature anaphase onset. In terms of microtubule dynamics its interaction with tubulin ensures that proper spindle architecture and tension are maintained throughout the mitotic process supporting the necessary stability for successful completion of cell division.
Dysregulation of ZNF207/BUGZ activity connects to cancer where abnormal expression or mislocalization leads to chromosomal instability a hallmark of many tumor types. Research also links ZNF207/BUGZ abnormalities to neurodegenerative disorders though details remain under investigation. In these contexts its interaction with proteins like TP53 in cancer or TAU in neurodegenerative conditions could provide insights into potential therapeutic strategies or biomarkers.