Abcam, ab229090, Anti-OLA1 antibody

Size: 100µL
Rabbit Polyclonal OLA1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human, Rat samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human OLA1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human OLA1. The exact immunogen used to generate this antibody is proprietary information.Q9NTK5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OLA1 also known as Obg-like ATPase 1 is a GTPase enzyme with a molecular weight of approximately 47 kDa. It belongs to the Obg family of P-loop GTPases. You can find OLA1 primarily in the cytoplasm but it's also present in the mitochondria under certain conditions. Studies show high expression of OLA1 in a variety of tissues including the liver brain and heart indicating its widespread presence and importance in cellular processes.
Biological function summary
This protein regulates cellular processes such as protein synthesis stress response and mitochondrial function. OLA1 acts as a molecular switch influencing the dynamics of the cytoskeleton and protein synthesis machinery. It is an integral part of a multi-protein complex involved in the regulation of translation initiation factor eIF2B suggesting a role in controlling protein production during stress conditions.
Pathways
The actions of OLA1 fit into broader networks controlling cellular stress and protein homeostasis. It plays a significant role in the oxidative stress pathway and impacts the unfolded protein response. OLA1 interacts with other proteins such as HSP70 and eIF2 modulating how cells adapt to the changing environment and ensuring proper protein folding and function. This highlights its integrative role in cellular adaptation mechanisms.
OLA1 shows associations with cancer and neurodegenerative diseases. Its overexpression or mutation can contribute to tumorigenesis by affecting cell growth and apoptosis. Research also links OLA1 to Parkinson's disease where it might influence mitochondrial dysfunction interacting with proteins like Parkin and PINK1. Understanding OLA1's involvement in these disorders offers potential insights for therapeutic targets.