Abcam, ab229831, Anti-COSMC antibody

Size: 50µL
Rabbit Polyclonal COSMC antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human C1GALT1C1 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human C1GALT1C1 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q96EU7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
COSMC also known as "core 1 β3-Gal-T-specific molecular chaperone" is a molecular chaperone that plays a significant role in the proper formation of glycoproteins. It has a mass of approximately 55 kDa and is primarily expressed in the endoplasmic reticulum (ER). COSMC assists in ensuring the stability and activity of the T-synthase enzyme which is important for the O-glycosylation process in cells.
Biological function summary
This target ensures accurate glycan biosynthesis by acting as a proper folding assistant for its enzyme partner T-synthase. As part of this functional duo COSMC does not operate alone but facilitates a complex where proper protein folding and expression are necessary. Without COSMC's guidance T-synthase becomes inactive resulting in improper glycosylation patterns that can affect cellular functionality and communication.
Pathways
COSMC-related activities are important in the O-glycan biosynthesis pathway which is important for the production of mucins and other glycoproteins involved in cell signaling and adhesion. This chaperone also interacts with proteins in the Golgi apparatus where it supports the biosynthetic pathway of type 1 and type 2 core structures. COSMC's interaction ensures accurate protein glycosylation which impacts several cellular processes.
Faulty COSMC function is linked to Tn syndrome where improper glycan synthesis leads to an accumulation of specific glycoprotein types that can disrupt normal cellular behavior. Aberrant glycan structures resulting from COSMC mutations also connect it to cancer progression as it relates to altered cell surface antigens. This protein's function or malfunction within these contexts highlights the potential connections with other proteins such as T-synthase in glycan-related diseases.