Abcam, ab230490, Anti-LIM domain only 3 antibody

Size: 50µL
Rabbit Polyclonal LIM domain only 3 antibody. Suitable for IHC-P, WB and reacts with Human, African green monkey samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human LMO3 aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:African green monkey, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human LMO3 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8TAP4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein known as LIM domain only 3 (LMO3) plays an important role in transcriptional regulation. Alternative names include LMO-3. It has a molecular mass of around 19 kDa. LMO3 contains two LIM domains which are specialized zinc finger-like structures essential for protein-protein interactions. This protein often functions in the nucleus facilitating interactions between different transcriptional machinery components. LMO3 is expressed in various tissues including the central nervous system and some smooth muscle tissues.
Biological function summary
LIM domain only 3 influences cell differentiation and development particularly within neuronal and muscle cells. The presence of LMO3 in these tissues allows it to act as a transcriptional modulator in developmental processes. It works by forming complexes with other proteins including transcription factors to either upregulate or downregulate gene expression. Through these complex formations LMO3 influences vital developmental processes and maintains cellular identity.
Pathways
Researchers recognize LIM domain only 3 as a component of the Wnt signaling pathway and Notch signaling pathway. In the Wnt pathway LMO3 associates with proteins like β-catenin which are important for regulating gene transcription and maintaining cellular homeostasis. In the Notch pathway LMO3 interacts with the Notch receptor influencing decisions on cell fate during development and growth.
The influence of LIM domain only 3 becomes apparent in various cancers and neurodevelopmental disorders. Aberrant expression of LMO3 has connections to certain cancers including neuroblastoma where it interacts with proteins like MYCN leading to enhanced tumorigenesis. Moreover dysregulation in LMO3 expression may contribute to neurodevelopmental disorders affecting normal brain development and function due to its role in cell differentiation.