Abcam, ab230626, Anti-Olig3 antibody

Size: 200µL
Rabbit Polyclonal OLIG3 antibody. Suitable for WB, IHC-P, Flow Cyt (Intra) and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human OLIG3 aa 50-100 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, Flow Cyt (Intra), IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human OLIG3 aa 50-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q7RTU3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Olig3 also known as Oligodendrocyte transcription factor 3 acts as a basic helix-loop-helix (bHLH) transcription factor. It has a mass of about 31 kDa and plays an important role in regulating gene expression. You typically find it expressed in developing neural tissues especially in the central nervous system. In humans it is located on chromosome 6 where its precise control is necessary for proper neural development.
Biological function summary
Olig3 regulates the development of specific neurons in the central nervous system. It does not operate alone but often forms heterodimers with other bHLH transcription factors to exert its influence. Researchers have shown its involvement in neurogenesis particularly in defining neuronal cell fate. By activating or repressing specific genes it fine-tunes the development of neural progenitor cells into specialized neuron types.
Pathways
Olig3 integrates into the Notch and Sonic Hedgehog signaling pathways. It influences neuronal differentiation through these pathways often interacting with proteins like Hes1 which is part of the Notch pathway. Sonic Hedgehog also plays a role in guiding the spatial expression patterns where Olig3 is active ensuring a balanced developmental process. These pathways are essential for the correct propagation of signals that dictate the specification of neuronal cell lineages.
Olig3 has been implicated in medulloblastoma and certain developmental disorders. Dysregulation of Olig3 expression and function can contribute to tumor formation in the cerebellum often in conjunction with associated proteins such as Gli1 from the Sonic Hedgehog pathway. Abnormalities in Olig3 expression may also link to developmental neuroissues due to its foundational role in neuron formation and differentiation.