Abcam, ab233005, Anti-PLSCR4 antibody

Size: 100µg
Rabbit Polyclonal PLSCR4 antibody. Suitable for WB, IHC-P and reacts with Mouse, Pig, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PLSCR4 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human, Pig,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PLSCR4 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9NRQ2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PLSCR4 also known as Phospholipid Scramblase 4 is a member of the scramblase family and involves in phospholipid translocation across membranes. This protein has a molecular mass of approximately 34 kDa. Expressed in various tissues PLSCR4 shows significant presence in hematopoietic cells and brain tissues. Its distribution suggests diverse functional roles across different physiological systems in the body.
Biological function summary
PLSCR4 functions in modulating cellular membranes' lipid asymmetry which is important for maintaining cell membrane fluidity and other processes. It does not generally form part of a larger complex acting more independently in its role compared to some members of the scramblase family. Through its activity PLSCR4 also has a potential role in signal transduction and apoptosis regulation where lipid dynamics are essential.
Pathways
PLSCR4 mainly connects to apoptotic signaling and immune response pathways. It influences events where membrane lipid composition is important for signaling transduction. Proteins such as caspases may interact or function in parallel as they participate with scramblase family members during apoptosis. PLSCR4's involvement in these pathways highlights its importance in cell death regulation and immune system functionality.
PLSCR4 may be involved in cancer and neurological disorders where dysregulated apoptosis and signaling can contribute to disease progression. Altered expression or function of PLSCR4 linked with proteins like Bcl-2 family members might influence cancer cell survival and resistance to apoptosis. In neurological contexts its expression levels and activity may affect neurodegenerative conditions through pathways involving cell survival and signaling maintenance.